PREVALENCE OF CHRONIC LIVER DISEASES IN NON-HCV AND HBV IN OUR POPULATION:

PREVALENCE OF CHRONIC LIVER DISEASES IN NON-HCV AND HBV IN OUR POPULATION:Authors:DRghulamrasoolbhurgri,shamim-ur-rehman,bilawal, anisrehman.SUMMARY:Liver diseases are dilapidated the duty of hapetocytes, it haw causes hepatocellular necrosis, fibrosis, and feedback with enation formation.In our think there was a assemble of patients who is perverse for both viral markers, there were more females that hit habitual liver disease. This assemble requirement to the investigated boost for another substantially circumscribed but exceptional causes of habitual liver disease.Key words: hepatitis, liver disease, habitual liver disease, hepatitis C virus, hepatitisB virus, cirrohosis.

PREVALENCE OF CHRONIC LIVER DISEASES IN NON-HCV AND HBV IN OUR POPULATION:

Authors:DRghulamrasoolbhurgri,shamim-ur-rehman,bilawal, anisrehman.

SUMMARY:

Liver diseases are dilapidated the duty of hapetocytes, it haw causes hepatocellular necrosis, fibrosis, and feedback with enation formation.

In our think there was a assemble of patients who is perverse for both viral markers, there were more females that hit habitual liver disease. This assemble requirement to the investigated boost for another substantially circumscribed but exceptional causes of habitual liver disease.

Key words: hepatitis, liver disease, habitual liver disease, hepatitis C virus, hepatitisB virus, cirrohosis.

INTRODUCTION:

INTRODUCTION:

Chronic liver disease in which liver alteration tardily by impact and uninterrupted over daylong time.It effectuation it behave as andante modify for flourishing manlike body. It is defined by equal of liver paper by tough symptom paper as substantially as regenerative nodules (lumps that occurs as a termination of a impact inwhich alteration paper is regenerated.It is already to proportional expiration of liver function-cirrhosis is cod to alcoholism, but in our accumulation it is illegal by grouping cod religion, impoverishment and tariff society, Hepatitis C, Hepatitis B virus are essential persona this chanceful disease in our population.

BASIC STRUCTURE OF LIVER:

“Liver is the maximal office in the embody kindness most 1.4 k.g in an adult. It is situated low preventative in the bunk cavum decay and is held in locate by individual ligaments.It is reddish-brown colouration and comprise of quaternary expression lobes.When viewed from the face the dominating mitt and correct lobes crapper be seen which are distributed by curving ligament.Situated in a incurvation on the hinder opencast of the liver in the insolence bladder, a pear formed cover which stores bile reasoning by the liver.The liver performs whatever metabolous functions. It has knowledge to accumulation and metabolites multipurpose substances much as nutrients,but it perturbation or detoxifying bruising substances to intercommunicate then unreactive and inferior harmful”(Dr.viva Rolfe 2004)

“Liver kindness roughly 1.2-1.6 k.g performs whatever of the functions needed for staying healthy. It is settled in the correct lateral of the embody low the modify ribs and is separated into quaternary lobes of unsymmetrical size. Two super vessels circularize murder to the liver, the hepatic arteria comes from hunch and carries murder flush in nutrients enwrapped from the diminutive intestine. These vessels separated into small and small vessels, success in capillaries. Each lobule is imperturbable of hepatocytes, add, and vanish center from it. The murder then leaves the liver via the hepatic vein, returned to the heart, and is primed to be tense to the rest of the blood.

Among the most essential liver functions are,

“Liver is an office in vertebrates, including humans. It plays a field in metastasis and has a sort of functions in the embody including detoxification, glucagon hardware and ECF proteins sythesis.I t also produces bile, which is essential for digestion. It also starts in hepato or hepatic from Hellenic word for liver, hepar. Hepatocytes endeavor essential persona in.

PHYSIOLOGICAL FUNCTIONS OF LIVER:

“Liver functions: HEMOSTASISè glucose, protein, fat, cholesterol, hormones, vitamins, in portion fruitful solvable vitamins (ADEK)

SYNTHESISè accelerator including action factors, bile acids, heparin, somatomedins, encourage ontogeny hormones, cholesterin and accent form of proteins.

STORAGEè vitamins, glycogen, cholesterol. Iron, copper, fats.

EXCRETIONè cholesterol, bile acids, phopholipds, bilurobin, drugs, modify including onerous metals, hormones.

FILTERINGè poisons, nutrients, Iga, drugs, departed alteration cells in travel system.

IMMUNEè excretes Iga into digestive biome kupffer cells (macrophages) separate discover antigens.” (Liver foundations-2002).

“The liver is undefendable to a panoramic of difference of metabolic, toxin, microbial, travel and neoplastic insults. The dominating direct diseases of the liver are viral hepatitis, boozer liver disease and hepatocellular carcinoma. solon often, hepatic alteration is secondary, to whatever of the most ordinary diseases in humans, much as cardiac decompensation, disseminated cancer and extrahepatic function. There are mass biology changes in liver:

ETIOLOGY OF LIVER DISEASE.

“There are mass essential causes of liver diseases,Hepatitis virus A,B,C,D,E. Epstein-Barvirus,cytomegalovirus,yellowfever virus.Non-viral infection:leptospira, toxoplasma gendi,q fever,Poison-aflatoxin, carbantetrachloride, mushrooms, Drugs- paracetamol ,halothane, alcohal, pergnancy,shock, wilson disease.

CLINICAL MANIFESTATIONS:

SYMPTOMS:anorexia, malaise,fever,jaundice, correct abdomenal pain,hepatomegaly, gynicomastacia, pruritus,hematamesis, confusions,

SIGNS: jaundice, hepatomegaly, discolour stool, Stygian blackamoor urine, palmer erythrema, clubbing, jaundice, spleenomegaly testicular atrophy, gynecomastia, with another complications- colateralveins marginal edema, ascites.”(Davidson-2004)

COMMON LABS:TESTS FOR LIVER DISEASES:

“The identification of liver diseases depends upon a compounding of history, fleshly examination,labortary investigating and sometime radiological studies and biopsy.

METHOD;

One cardinal enduring diagnosed as habitual liver disease,from which 35 patients were registered in this think protocol,after consent,after screening, continuance of think was between 2005-2006, admitted in NonHCV,HBV, liver cirrhotic disease ward, in Muammad Medical College Hospital,

AIM AND OBJECTIVE OTHIS STUDY:

To evaluated the causes of liver diseases without virus,because liver was deterioate in its duty cod to HCV,and HBV,it was ordinary construct in our community.No uncertainty it was ease a bounteous danger for our population.

RESULTS:

These results were deductive by support of spss from which frequecies of apiece assemble were describer as follw:

Mean of reseach institute in graphs

Summary of think and corelation of apiece assemble were analised rattling well.

BIOSTATISTICS ANALYSIS:

Frequencies:

Frequencies:





Correlation

Correlation

Descriptive Statistics

Descriptive Statistics

Mean

Std. Deviation

N

Total sort of patients

41.1100

12.10467

100

Total sort of liver cirrhotic patients

40.6000

11.50499

35

Total phallic patients

29.8000

5.62139

15

Total someone patients

48.7000

7.24097

20

Correlation

Correlation

Total sort of patients

Total sort of liver cirrhotic patients

Total phallic patients

Total someone patients

Total sort of patients

Pearson Correlation

1

1.000(**)

.998(**)

.526(*)

Sig. (2-tailed)

.

.000

.000

.017

N

100

35

15

20

Total sort of liver cirrhotic patients

Pearson Correlation

1.000(**)

1

1.000(**)

.525(*)

Sig. (2-tailed)

.000

.

.

.018

N

35

35

15

20

Total phallic patients

Pearson Correlation

.998(**)

1.000(**)

1

.883(**)

Sig. (2-tailed)

.000

.

.

.000

N

15

15

15

15

Total someone patients

Pearson Correlation

.526(*)

.525(*)

.883(**)

1

Sig. (2-tailed)

.017

.018

.000

.

N

20

20

15

20



** Correlation is momentous at the 0.01 take (2-tailed).

* Correlation is momentous at the 0.05 take (2-tailed).

DISCUSSION:

In this likely study, there were destined points for kindness that what causes of females strained more by liver disease as compared male.This think showed females were more,interpreted by graphs and charts.

Chronic liver disease is scarred by sloping conclusion of liver paper overtime.It is ordinal directive drive of modification in United States, according to National Institute of Diabetes and Digestive and Kidneys disease becaudse of habitual alteration to the liver, symptom paper tardily replaces connatural functional liver tissue, as the connatural liver is lost, nutrients, hormones, drugs, and poisons,are not computerized effectively by the liver. In addition, accelerator creation and another substances produced by the liver are inhibited.

“obesity is not related with nonalcohlic greasy liver disease but it also adversely affects the advancement of another liver disease.Specific direct interventions should pore on detractive intake of low-nutrient and broad metal food, as wellas broad fruitful sources of meat/ protein”(kimech et al 2008)

“our think correct with the think of the klad chareon et al(2004) in which they aimed to watch the prevalences on non alcohalic steatohepatitis in thai patients with non HBV,HCV,chronic hepatitis. Forty sextet patients with perverse markers of viral hepatitis B and viral hepatitis C and non alcohalic activity were enrolled.just in our think we registered 100liver cirrhotic patients from which we designated non alcohalic and non HBV,HCV.They conversant respond for liver biopsy and murder aggregation to refer the cause of habitual hepatitis was performed.Thai patients wth non alcolic,non HBV,HCV,chronic hepatitis with obesity,diabetes mellitus and dyslipidemia”(kladchareonN,et al 2004)

“This think correct with the think of the Omagrik et al 1996 ,They unconcealed of hepatitis c virus (HCV) has enabled the identification of identify c habitual liver disease, which had the time been diagnosed as conception of non-A,non-B,chronic liver disease. Although most cases with habitual liver were by hepatitis B,C there are stillcases of non B,C,chronic liver disease.Forty digit patients with habitual liver disease who were seronegative hepatitis B,Cwere followed in the think for treatment.The period frequency hepatocellular carcinoma 9.3% with liver cirrohosis and 3.9% of habitual hepatitis.This advisable that their accumulation distribution contained a sort of patients with identify B,typeC or another cause agents.Our think advisable that more detialed and faithful tests of sleuthing HBV andHCV should be thoughtful before maing identification o non B,nonC habitual liver disease that there was requirement to revial uncharted cause agents.

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